top of page

How sleep loss hurts your brain

New science reveals the hidden toll on blood sugar, waste clearance and more!

By Austin Perlmutter, MD



  • A number of recent studies highlight new pathways connecting sleep and brain health

  • Sleep deprivation is now linked to more rapid brain aging

  • An essential brain cleaning system may be slowed without adequate deep sleep

  • Missing out on good sleep may damage healthy blood sugar levels

  • Prioritizing good sleep remains among the most important things you can do for your brain

We’ve all experienced what it’s like to be short on sleep. Whether it’s a night cut short by a very early morning awakening, one punctuated by frequent waking, or even a night of sleep skipped altogether, there are any number of things that can get in the way of the recommended 7-9 hours of restful slumber. But while we may feel a bit groggy, slow and otherwise fatigued after sleep loss, recent research suggests that there are a few specific effects on the brain worth knowing.

1. Our brains may age more rapidly during sleep deprivation

In a just-published 2023 paper, researchers examined the effects of sleep deprivation on markers of brain aging using MRI scanners. Using previously published data, the scientists compared brain aging scores between different groups of young people and found that those experiencing a sleep deprivation of at least 24 hours showed brain scans equivalent to 1-2 years of brain aging. On a positive note, they found that these changes were reversed after a good night’s sleep.

2. An essential brain cleaning system may be slowed without adequate deep sleep

One of the most fascinating breakthroughs in neuroscience over the last decades relates to the discovery of the glymphatic system, a network of channels in the brain that allow for clearance of brain waste. If that wasn’t enough, it turns out that this system is more active during sleep and especially deep sleep (non-REM). To take this one step further, a paper published in the journal Science found that clearance of waste occurs in a wave-like pattern that is synchronized with the firing of neurons and with blood flow.

3. Missing out on good sleep may damage healthy blood sugar levels

Blood sugar issues like type 2 diabetes and prediabetes have become incredibly common and are slated to impact billions in the decades to come. The well-known associations between these conditions and immune, kidney cardiovascular as well as brain diseases make it all the more important that we better understand what’s controlling our blood sugar. It’s now been established that sleep may be one major regulator.

It's been well established that sleep deprivation damages healthy blood sugar and insulin function, while getting good sleep may have the opposite effect. Yet the reasons why have remained less clear. In a paper just published by a team including sleep expert and author of Why We Sleep, Dr. Matthew Walker, researchers looked at associations between markers of sleep brainwaves and blood sugar markers the next day. After examining hundreds of people, they found that certain patterns of brain activity measured during deep sleep (non-REM) significantly predicted fasting blood sugar measurements the next day. The researchers concluded that their findings suggest a link between sleep and blood sugar regulation. They also draw attention to the significance of this result in the context of management of blood sugar issues like diabetes.

It’s clear that research like the studies above will continue to reveal the hidden effects of sleep loss on the brain. Beyond the well-known links to increased risk for mental health issues, dementia, worse decision-making and poor focus, these new mechanisms speak to the vital importance of prioritizing good sleep each night. Luckily, simple and science backed ways to improve sleep quality are available to all of us.

Want FREE access to more life-changing health science from

Dr. Austin Perlmutter?> Click HERE

624 views0 comments

Recent Posts

See All
bottom of page